DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts
نویسندگان
چکیده
منابع مشابه
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
Dicer, an enzyme involved in microRNA (miRNA) maturation, is required for proper cell differentiation and embryogenesis in mammals. Recent evidence indicates that Dicer and miRNA may also regulate tumorigenesis. To better characterize the role of miRNA in primary cell growth, we generated Dicer-conditional mice. Ablation of Dicer and loss of mature miRNAs in embryonic fibroblasts up-regulated p...
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Caveolae are vesicular invaginations of the plasma membrane. Caveolin-1 is the principal structural component of caveolae in vivo. Several lines of evidence are consistent with the idea that caveolin-1 functions as a "transformation suppressor" protein. In fact, caveolin-1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes. Interestingly, the human...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2013
ISSN: 1474-9718
DOI: 10.1111/acel.12117